The article aims to analyse gender segregation in the labour market while comparing two national contexts in Europe and Latin America. Specifically, it will consider the growth trends of female employment in the last 25 years (1992-2017), its distribution between activity sectors and occupations, and the gender pay gap. Feminization models and gender inequalities are framed within labour market segmentation theories, which are in partial contrast to human capital theories and neoclassical economics. The initial hypothesis is that the gender distribution of occupations measured by a segregation index is similar in Italy and Chile, despite significant differences in the socio-economic and institutional contexts. Through this intercontinental comparison, the article intends to shed light on women's labour market conditions and segregation patterns, which are multidimensional and generalizable (transcontinental) phenomena, connected to the unequal division of labour in the new post-industrial order.