ABSTRACT Nanocomposite polymers have received considerable interest in research for the last three decades. Those nanocomposite polymers that are sensitive to a stimulus such as pH, temperature, magnetism, and electricity, among others, called smart or intelligent nanocomposite polymers had received even greater attention due to their potential technological applications. Applications of these polymers include flexible electronic devices, sensors, self-healing polymers, shape-memory materials, etc. The sensitivity of the material can come from both the polymer that acts as a matrix and the nanofiller, resulting in a material that combines properties of each of its components and that each one will not have separately. This mini-review aims to provide an update on the most recent and significant applications in the area of stimuli-responsive polymer nanocomposites, emphasizing the most innovative applications in biomedicine and catalysis developed in the last three years.