Abstract This research aims to explore the university-industry collaboration in a public university in Mexico. This research considers the researchers´ perception of organizational factors and the researchers´ characteristics as drivers of the university-industry collaboration. The research design of this study was quantitative. Findings indicate that the researchers´ participation in innovation projects is low. The researchers´ perception about some organizational factors to collaborate with industry is negative. Data shows that researchers consider complicate to establish a relationship with industry that is mainly related to organizational factors. In addition, important findings of this study suggest that researchers´ gender influence the university-industry collaboration.