There are currently more than 930 edifications with heights of 200 m or more around the world, which has created new challenges in earthquake engineering. Previous investigations and seismic design codes recognize that dynamic soil-structure interaction can have significant effects on the seismic response of such tall buildings. The researches have shown that variables such as the basement depth, the retaining wall flexibility, the soil characteristics, and the earthquake characteristics need to be considered to properly evaluate the dynamic response. These variables can modify the lateral seismic pressures on the basement walls, the distribution of inter-story drifts, and the ground motion at the foundation level. This study examines the seismic response of a tall building with deep basement considering soil-structure interaction. The structural configuration of the structure was based on typical configurations used for tall buildings in Santiago, Chile. The dynamic behavior of such structure is evaluated using non-linear finite element analysis. The lateral seismic pressures on the basement walls was characterized, and the differences between the free-field and the founda-tion-level ground motion were determined.