Hepatocellular carcinoma (HCC) is the most common primary liver malignancy with increasing incidence over the last number of years. Since most are diagnosed in the setting of cirrhosis, the vast majority of cases arise in geographic areas where Hepatitis B and Hepatitis C are prevalent. Other risk factors such as alcohol and non-alcoholic steatohepatitis (NASH) are involved in the pathogenesis of HCC. In terms of the diagnosis of HCC, ultrasonography (US), CT-Scan, and MRI all play a role and here, and we intend to discuss the rationale of the use of each imaging modality. In terms of HCC management, there are multiples staging systems that categorize different lesions according to liver function and tumor characteristics in order to select the most appropriate treatment modality for each case.