The work aims to perform a semiotic reading according to the presence of the fantastic in the poem “La desaparición de una familia” by Juan Luis Martínez. In this regard, a broad framework of concepts related to fiction reading is articulated (Umberto Eco, Roland Barthes, Jean-Luc Nancy, among others), the understanding of the fantastic as a semiotic system (David Roas, Omar Nieto), the anthropophagy (Rodrigo Browne) and the notion of picnolepsy (Paul Virilio). With everything, it is intended to form an initial idea of semiotic of the disappearance as a particular quality of the poem.