Computers & Chemical Engineering (CCE) is one of the premier international journals in the field of chemical engineering. CCE published its first issue in 1977 and completed forty years in 2016. More than four decades of continuous and successful journey influenced us to celebrate its contribution through a comprehensive bibliometric study. Using the Web of Science Core Collection database we depict trends of the journal in terms of papers, topics, authors, institutions, and countries. Networks visualization of co-citation of journals and authors, bibliographic coupling institutions and countries, and co-occurrence of author keywords are prepared using the visualization of similarities (VOS) viewer software. The present analysis explores publication and citation patterns of the journal. Professor Ignacio E. Grossmann, Carnegie Mellon University, and USA respectively appear as the most productive and influential author, institution, and country in CCE publications. Optimization based research topics received most attention in CCE publications.