Tires are an industrial waste that has become a worldwide environmental problem. To minimize this effect, tire waste is used in construction as a concrete aggregate. Additionally, carbon dioxide in the atmosphere affects the carbonation of concrete. This study analyzes the effect of carbonation in concrete with tire rubber aggregate as a 0%, 10%, 20%, 30%, 40%, 50% and 60% proportional replacement for the fine aggregate. The carbonation test was conducted for 2, 4, 6 and 24 hours. The compressive strength of the concrete decreased depending on the tire rubber content in the mixes, while the concretes with tire rubber percentages greater than 30% were affected by carbonation.