Background: The objective was to describe the changes in functionality after the use of virtual reality in post Total Knee Arthroplasty (ATR) participants. Materials and methods: 25 post-operated ATR participants were recruited. The virtual reality training lasted 6 weeks. The outcome measures were the WOMAC questionnaire; the Berg Balance scale; pain with visual analogue scale (VAS); distance covered with the 6-minute Walk Test and the difference in weight load on the lower extremities. Results: At the end of the treatment, all the variables studied showed statistically significant reductions (p < 0.05). Conclusions: Physiotherapeutic training that adds virtual reality, in the short term, improves functionality in post-operated ATR participants.