One key factor in the studies carried out on cross-border regions, are the value chains that are established through economic trade. This article examines this issue with respect to the Dominican Republic/Haitian border (Elias Pina-Departamento Central), through an analysis of agri-food chains. For this purpose, a study was made of six agricultural products that cross the border in both directions. This work included observations, the gathering of statistical data, and interviews with key stakeholders in these processes. The value chains highlight typical features of unequal cross-border trade. Moreover, they also show how the region, and specifically local producers, have limited access to the profits generated by such cross-border economic activity.