Dataciencia

Colección SciELO Chile

Photothermally Controlled Methotrexate Release System Using beta-Cyclodextrin and Gold Nanoparticles

Indexado

WoS	WOS:000455323100023
Scopus	SCOPUS_ID:85057893206

DOI

10.3390/NANO8120985

Año

2018

Tipo

artículo de investigación

Citas Totales

Autores Afiliación Chile

Instituciones Chile

% Participación
Internacional

Autores
Afiliación Extranjera

Instituciones
Extranjeras

Abstract

The inclusion compound (IC) of cyclodextrin (CD) containing the antitumor drug Methotrexate (MTX) as a guest molecule was obtained to increase the solubility of MTX and decrease its inherent toxic effects in nonspecific cells. The IC was conjugated with gold nanoparticles (AuNPs), obtained by a chemical method, creating a ternary intelligent delivery system for MTX molecules, based on the plasmonic properties of the AuNPs. Irradiation of the ternary system, with a laser wavelength tunable with the corresponding surface plasmon of AuNPs, causes local energy dissipation, producing the controlled release of the guest from CD cavities. Finally, cell viability was evaluated using MTS assays for beta-CD/MTX and AuNPs + beta-CD/MTX samples, with and without irradiation, against HeLa tumor cells. The irradiated sample of the ternary system AuNPs + beta-CD/MTX produced a diminution in cell viability attributed to the photothermal release of MTX.

Revista

Revista	ISSN
Nanomaterials	2079-4991

Métricas Externas

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Disciplinas de Investigación

WOS
Materials Science, Multidisciplinary
Nanoscience & Nanotechnology

Scopus
Sin Disciplinas

SciELO
Sin Disciplinas

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Publicaciones WoS (Ediciones: ISSHP, ISTP, AHCI, SSCI, SCI), Scopus, SciELO Chile.

Colaboración Institucional

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Autores - Afiliación

Ord.	Autor	Género	Institución - País
1	SILVA-GONZALEZ, NATALY ROXANA	Mujer	Universidad de Chile - Chile Universidad de Santiago de Chile - Chile
2	RIVEROS-SALVATIERRA, ANA LUISA	Hombre	Universidad de Chile - Chile
3	RADIC-FOSCINO, DEODATO	Hombre	Universidad de Chile - Chile
4	LANG-PONTONY, ERIKA PATRICIA	Mujer	Universidad de Chile - Chile
5	CHORNIK-ABERBUCH, BORIS	Hombre	Universidad de Chile - Chile
6	GUERRERO-RIVERA, SIMON JUAN	Hombre	Universidad de Chile - Chile
7	Samitier, Josep	Hombre	Barcelona Inst Sci & Technol - España Ctr Invest Biomed Red Bioingn Biomat & Nanomed CI - España Univ Barcelona - España Instituto de Bioingeniería de Cataluña - España CIBER Bioingenieria, Biomateriales y Nanomedicina - España Universitat de Barcelona - España Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina - España
8	JARA-VERGARA, PAUL SEBASTIAN	Hombre	Universidad de Chile - Chile
9	KOGAN-BOCIAN, MARCELO JAVIER	Hombre	Universidad de Chile - Chile

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Financiamiento

Fuente
FONDECYT
FONDAP
FONDECYT Postdoctoral
MECESUP
Fondo Nacional de Desarrollo Científico y Tecnológico
European Regional Development Fund
Universidad de Santiago de Chile
Ministerio de Ciencia e Innovación
Instituto de Salud Carlos III
Center for International Business Education and Research, University of Illinois at Urbana-Champaign
Consolider Program
Commission for Universities and Research of the Department of Innovation, Universities, and Enterprise of the Generalitat de Catalunya
Scholarships Conicyt N.S. Grand, BECAS CHILE Convocatoria 2011
VI National R&D&i Plan 2008-2011
Iniciativa Ingenio 2010
laboratory NMR USACH (Bruker Avance)
Generalitat de Catalunya through the CERCA program
MIND - Spanish Ministry of Science and Innovation (MICINN) under the National Program for the internationalization of RD
Spanish Ministry of Economy, Industry and Competitiveness through the Centro de Excelencia Severo Ochoa Award
CIBER Actions

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Agradecimientos

Agradecimiento
The authors would like to express their gratitude for the support from the laboratory NMR USACH (Bruker Avance 400 MHz). We thank the Kampar oncology laboratory for the donation of the Methotrexate drug. Fondecyt 1170929, 1171611, and 1160114. Scholarships Conicyt N.S. Grand AT-24121127, BECAS CHILE Convocatoria 2011. Fondecyt Postdoctoral 3150271. Fondap 15130011. MECESUP 0811. This work was partially supported by the MIND funded by the Spanish Ministry of Science and Innovation (MICINN) under the National Program for the internationalization of R&D, the Spanish Ministry of Economy, Industry and Competitiveness through the Centro de Excelencia Severo Ochoa Award and by the Generalitat de Catalunya through the CERCA program. CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. The Nanobioengineering group has support from the Commission for Universities and Research of the Department of Innovation, Universities, and Enterprise of the Generalitat de Catalunya (2014 SGR 1442).
The authors would like to express their gratitude for the support from the laboratory NMR USACH (Bruker Avance 400 MHz). We thank the Kampar oncology laboratory for the donation of the Methotrexate drug. Fondecyt 1170929, 1171611, and 1160114. Scholarships Conicyt N.S. Grand AT-24121127, BECAS CHILE Convocatoria 2011. Fondecyt Postdoctoral 3150271. Fondap 15130011. MECESUP 0811. This work was partially supported by the MIND funded by the Spanish Ministry of Science and Innovation (MICINN) under the National Program for the internationalization of R&D, the Spanish Ministry of Economy, Industry and Competitiveness through the Centro de Excelencia Severo Ochoa Award and by the Generalitat de Catalunya through the CERCA program. CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008–2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. The Nanobioengineering group has support from the Commission for Universities and Research of the Department of Innovation, Universities, and Enterprise of the Generalitat de Catalunya (2014 SGR 1442).

Agradecimiento

The authors would like to express their gratitude for the support from the laboratory NMR USACH (Bruker Avance 400 MHz). We thank the Kampar oncology laboratory for the donation of the Methotrexate drug. Fondecyt 1170929, 1171611, and 1160114. Scholarships Conicyt N.S. Grand AT-24121127, BECAS CHILE Convocatoria 2011. Fondecyt Postdoctoral 3150271. Fondap 15130011. MECESUP 0811. This work was partially supported by the MIND funded by the Spanish Ministry of Science and Innovation (MICINN) under the National Program for the internationalization of R&D, the Spanish Ministry of Economy, Industry and Competitiveness through the Centro de Excelencia Severo Ochoa Award and by the Generalitat de Catalunya through the CERCA program. CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. The Nanobioengineering group has support from the Commission for Universities and Research of the Department of Innovation, Universities, and Enterprise of the Generalitat de Catalunya (2014 SGR 1442).

The authors would like to express their gratitude for the support from the laboratory NMR USACH (Bruker Avance 400 MHz). We thank the Kampar oncology laboratory for the donation of the Methotrexate drug. Fondecyt 1170929, 1171611, and 1160114. Scholarships Conicyt N.S. Grand AT-24121127, BECAS CHILE Convocatoria 2011. Fondecyt Postdoctoral 3150271. Fondap 15130011. MECESUP 0811. This work was partially supported by the MIND funded by the Spanish Ministry of Science and Innovation (MICINN) under the National Program for the internationalization of R&D, the Spanish Ministry of Economy, Industry and Competitiveness through the Centro de Excelencia Severo Ochoa Award and by the Generalitat de Catalunya through the CERCA program. CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008–2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. The Nanobioengineering group has support from the Commission for Universities and Research of the Department of Innovation, Universities, and Enterprise of the Generalitat de Catalunya (2014 SGR 1442).