Obesity is a serious condition affecting the physical and psychological well being of a large number of individuals. There are many therapeutic options for the disease and their judicious selection is critical. The best results are obtained with well-organised multi professional programs. The aims of the treatment must be defined balancing risks and benefits. Eating behaviour patterns must be considered for the proper selection of therapy. Diet is an essential therapeutic component and has to be individually prescribed for each patient. Pharmacological agents inhibit appetite, increase thermogenesis or inhibit gastrointestinal absorption of nutrients. As these medications have important side effects and complications, extreme care must be taken for their prescription.