Colección SciELO Chile

Departamento Gestión de Conocimiento, Monitoreo y Prospección
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Chilean experience with the use of an oral contraceptive combination of chlormadinone acetate plus ethinylestradiol: Noninterventional study Experiencia chilena con el uso de un anticonceptivo oral combinado de acetato de clormadinona/etini-lestradiol: Estudio no intervencional
Indexado
Scopus SCOPUS_ID:64549155354
DOI
Año 2008
Tipo

Citas Totales

Autores Afiliación Chile

Instituciones Chile

% Participación
Internacional

Autores
Afiliación Extranjera

Instituciones
Extranjeras


Abstract



Objectives: To evaluate the efficacy, tolerability and safety of the contraceptive Belara®(chlormadinone 2 mg/ethinylestradiol 0.03 mg; ACM/EE) in Chilean women. Methods: Non interventional, multicentric, prospective, 6 cycles follow up trial, evaluating contraceptive efficacy, cycle stability, tolerability, safety, and effect on hair and skin. Results: AMC/EE was taken by 593 women for a total of 3426 cycles. Two pregnancies were reported during follow-up, one voluntary and the other involuntary; they were not considered failure of the method. Progressive improvement in cycle stability, intermenstrual bleeding, amenorrhea and dysmenorrhea occurred during the treatment period reaching 4.5%, 1.4%, 2.5% y 11.6% at the 6th cycle respectively. The percentage of women with normal skin increased from 25.5% prior to treatment, to 63.6%, after taking ACM/EE during six months. The average body weight was maintained throughout treatment. The most frequent adverse events were: headache (10.4%), weight increase (8.3%), breast tenderness (6.1 %) and mood changes (2%). An 11 % of users (n=63) discontinued the use of ACM/EE before completing the observational period of six months. A 97.2% of physicians and 96.1% of users qualified the results with ACM/EE as "good or very good". Conclusions: Similar to the results reported in the European literature, this study in the Chilean population confirmed the efficacy, safety and tolerability of ACM/EE, together with its antiandrogenic benefits on skin and hair, and its neutral effect on body weight.

Disciplinas de Investigación



WOS
Obstetrics & Gynecology
Scopus
Obstetrics And Gynecology
SciELO
Health Sciences

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Publicaciones WoS (Ediciones: ISSHP, ISTP, AHCI, SSCI, SCI), Scopus, SciELO Chile.

Colaboración Institucional



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Autores - Afiliación



Ord. Autor Género Institución - País
1 Andrea Schilling, R. - Clínica Alemana - Chile

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Financiamiento



Fuente
Sin Información

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Agradecimientos



Agradecimiento
Sin Información

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