One of the proposed treatments for extrinsic skin aging processes is Grape therapy, whose active ingredients, known to possess antioxidant properties, are the vegetable and seed oil extracts from the Vitis Vinífera L. grape species. The objective of the present work was to evaluate the release of polyphenol compounds from these extracts, retained in gel and emulsion based cosmetic formulations, using Franz diffusion cells. A quantifi cation of total active ingredient release was also carried out using the Folin Denis visible spectrophotometry method. Polyphenol release from both types of formulation was found to follow a square root of time kinetic model, but a higher rate of release was obtained from the gel formulation.