In this paper, we examine the presence of Iran in Latin America through its connections with three countries that are members of the "Alternativa Bolivariana para América Latina y el Caribe" (ALBA)-Venezuela, Nicaragua, Bolivia-and one that is an observer of this association-Ecuador-. We argue that these relations cover not only the economic level, but incorporate also the political, cultural and military levels. This is a strategic relationship in which both sides seek political advantages. On one hand, Iran seeks to overcome its international isolation and present itself as a platform of opposition to the United States; on the other hand, framing the latter in the context of SouthSouth relations.