Bone remodeling is fundamental to orthodontics and dentofacial orthopedics.This clinically oriented overview relate bone responses to orthodontic forces with many factors. Molecules produced in various diseased tissues, or drugs and nutrients consumed regularly by patients, can reach the mechanically stressed paradental tissues through the circulation, and interact with local target cells. The combined effect of mechanical forces and one or more of these agents may be inhibitory, additive or synergistic. The objective of this review is to outline the mechanisms of action and effects of some commonly used drugs and other factors on tissue remodeling and orthodontic tooth movement.