Objectives:To describe the main demographic and clinical characteristics of Chilean patients with Spondyloarthritis included in the Ibero American Spondyloarhtritis Registry (RESPONDIA). Patients and methods: Descriptive and cross-sectional study of Chilean patients with Spondyloarthritis registered in the RESPONDIA database. Five Chilean university hospitals participated in the inclusion of patients (4 from Santiago and 1 from Valparaiso), between January 2006 and December 2007, according to the defined protocol. Results: 109 patients were included in the registry, 66 males (58.4%) with an average age of 42 ± 22 years, and average disease duration of 7.1 years (range 1-29 years). Diagnoses of the patients were Ankilosing Spondylitis (58.7%), Psoriatic Arthritis (25.6%), Undifferentiated Spondyloarthritis (7.3%), Inflammatory Bowel Disease Arthritis (5.5%), Juvenile Onset Spondyloarthritis (1.8%) and Reactive Arthritis (0.9%). Regarding clinical forms, 42.5% had mixed disease, 36.3% had axial disease, and 9.7% had peripheral disease. Inflammatory low back pain was the most frequent symptom reported (74.3%) followed by arthritis of the lower extremities (59.3%). The most common extra-articular disease manifestation was uveitis (18.6%). Some kinds of work disability were reported in 40% of the patients. Conclusions: The most frequent clinical profile in this group of Chilean patients with Spondiloarthritis was the combination of axial and peripheral diseases. The most common diagnosis was ankilosing spondylitis and psoriatic arthritis.