Lymphoma-like lesion of the cervix is an uncommon benign lymphoid proliferation that mimics large B-cell lymphoma (LBCL) and hence is a potential cause of misdiagnosis. We report a 24 year-old woman with an abnormal PAP smear and a subsequent cervical biopsy that showed an atypical lymphoid proliferation. Histopathologically, it was characterized by a superficial polymorphic lymphoid infiltrate with numerous scattered large cells, with no necrosis or sclerosis. Surface epithelium showed erosion and mild dysplasia. Immunohistochemically, the large atypical cells were positive for CD20 and the scattered large cells for CD30, with no expression of light chains. In situ hybridization for EBV was positive in a few isolated large cells. PRC amplification of the FR3 region of the IgH heavy chain showed 2 monoclonal bands. Two years later the patient is alive and well. © 2011 SEAP y SEC.