Background. Reducing the rate in IVF of multiple births and associated perinatal complications has become the major challenge in Latin America, due to is association with a significant increase in the prematurity, and perinatal mortality. Methods. We selected all procedures involving the transfer of IVF embryos, reported to the Latin America Registry of ART, initiated between January 1998 and December 2008. A Poisson regression analysis was performed, stratified by woman's age to analyse the trend in the transfer of 2, 3 and ≥4-embryos and ≥triple-pregnancy rate. Results. A total of 164,874 IVF/ICSI transfers were considered. Overall, there was a decline in the proportion of procedures performed in women aged ≤34 years old from 51% to 43%; and an increase of ICSI procedures from 61% to 86%. All age groups experienced a reduction in the proportion of ≥4-embryos transfers and an increase in that of 2-embryo transfers. Overall, the clinical pregnancy rate improved from 29% to 35% (p=0.01); and the incidence of ≥triple-pregnancy decreased from 8% to 3% in 2008 (p<0.001), while twin pregnancy remained stable (~20%) Conclusions. Our data support the policy of transferring less embryos. It shows a decline in the mean number of embryos transferred and proportion ≥ 4-embryos transfers. Moreover, it reports a clinical pregnancy rate which instead of being reduced, has shown an increase over the 10-year period. © Todos os direitos reservados a SBRA - Sociedade Brasileira de Reprodução Assistida.