Diverse studies in adverse medical events evidence a connection between the problems of usability and the errors in the use of medical devices. The objective of this work is to study the usability of medical devices using the Human Factor engineering analysis. This work is focused on the creation of evaluation tools for medical devices. Specifically, developing a methodology for the analysis of the usability of medical devices, based on the application of the Human Factor engineering to the tasks carried out by the user when interacting with a blood glucose monitor. This way, we determine which medical device is safer for the user's health through comparative analysis between three different manufacturers. The results show that this kind of analysis allows us to compare medical devices from another perspective, detecting important differences between them. © 2013 Springer.