Background: This 23rd report represents the results of ART procedures performed during 2011 by 145 centers from 12 countries in Latin America. This is the second time the data was individually collected in a case-by-case modality. Methods: All centers reported their ART procedures electronically and their data was accepted after consistency checks were performed and an accreditation team certified the institution. A total of 41,232 procedures included 28,065 initiated fresh homologous ART cycles consisting of 4,089 in vitro fertilization (IVF) cycles; 23,976 Intra cytoplasmic sperm injection (ICSI); 6,909 frozen embryo transfers (FET) and 6,258 oocyte donations (OD), plus 14 cases of GIFT, which are not described in this report. Results: Thirty eight percent of ET in IVF/ICSI cycles were performed in women age 35-39 years, while 25% included women ≥ 40. The delivery rate (DR) per ovum pick-up (OPU) in ICSI and IVF cycles were 20.7% and 23.9%, respectively. The multiple delivery rate in IVF/ICSI cycles grouped together, was 22.3% (21.0% twins and 1.3% triples). When ≥ 2 embryos were transferred, neither the CPR nor the proportion of twins increased significantly. However, the proportion of triplet increased significantly when ≥3 embryos were transferred. In OD cycles, twin and triplet deliveries were 28.5% and 1.6%, respectively. In FET cycles, twin and triplet deliveries were 17.8% and 1.4%, respectively. Multiple deliveries were associated with a significant increase in preterm delivery and perinatal mortality. In cases of elective transfers, the DR was 19.8% with eSET and 35.8% with eDET. In women aged ≤34 years, DR with eSET was 29.6% and 39.5% with eDET. Furthermore, in OD cycles, the DR with eSET was 25.0%, and 38.1% with eDET. Conclusions: Overall, delivery rates are acceptable and comparable to most developed countries in the world. However, Latin American countries need to enforce the reduction in the number of embryos transferred in IVF/ICSI and OD cycles, in order to decrease the rate of multiple births and therefore decrease the corresponding perinatal complications. © Todos os direitos reservados a.