The theoretical literature has explored the potential benefits of the interaction between universities and entrepreneurs and there is some empirical evidence that supports the positive impact of entrepreneurship education in the subsequent propensity to become an entrepreneur. The purpose of this paper is study if higher education for entrepreneurship is reflected in entrepreneurship activities at the regional level. Replicating the methodology used by Coduras, Urban, Rojas and Martínez (2008) in Spain, we compare, in an exploratory way, the experience in Chile using data from the Global Entrepreneurship Monitor (GEM). The main results indicate that there is low interaction between entrepreneurs and universities and there is not enough impact to significantly affect entrepreneurial activity. Moreover, entrepreneurship education does not increase intentions to be an entrepreneur. © Investigaciones Regionales.