Introduction: The relationship between socioeconomic position (SEP), migration and health is dynamic, difficult to predict, multifactorial and poorly studied in the Latin American region. Moreover, there are high levels of uncertainty about reasons, types, and consequences of migration to an individual, family, community, country of origin and the receiving country. Objective: To discuss the evidence about the complex relationship between SEP, migration and health outcomes. Results: According to international evidence available, migration has a direct impact on health outcomes in a population and, in turn, on public health policy decisions in each locality. The available evidence on this issue affects multiple parts of the social sciences. The "healthy migrant" effect is not consistently observed among immigrant populations, particularly after adjusting for PSE. Moreover, the immigrant population tends to assimilate in terms of risk factors and morbidity to the local population after about 10 years of stay in the foreign country. Migration has consequences for international relations, economic productive capacity of a country, inequality, demographic changes and health outcomes, to mention a few. Conclusion: There is now the opportunity to generate better and more evidence longitudinal population-based around the relationship between SEP, migration status and health. This will contribute to reduce uncertainty about the health status of immigrants that is required for decision- making in public health in Chile and the region. © 2014.