A 2D depth average model has been used to simulate water and sediment flow in the Brenta River so as to interpret channel changes and to assess model predictive capabilities. The Brenta River is a gravel bed river located in Northern Italy. The study reach is 1400 long and has a mean slope of 0.0056. High resolution digital terrain models has been produced combining laser imaging detection and ranging data with colour bathymetry techniques. Extensive field sedimentological surveys have been also carried out for surface and subsurface material. The data were loaded in the model and the passage of a high intense flood (R.I. > 9 years) was simulated. The model was run under the hypothesis of a substantial equilibrium between sediment input and transport capacity. In this way, the model results were considered as a reference condition, and the potential trend of the reach was assessed. Low-frequency floods (R.I. » 1.5 years) are expected to produce negligible changes in the channel while high floods may focalize erosion on banks instead than on channel bed. Furthermore, the model predicts well the location of erosion and siltation areas and the results promote its application to other reaches of the Brenta River in order to assess their stability and medium-term evolution.