The noise map of Santiago of Chile in 2011 showed that a significant part of its area and population are exposed to road traffic noise levels that are unacceptable or dangerous according to the Organization for Economic Cooperation and Development which Chile belongs to. Considering the multiple potential health effects generated by such exposure, and taking into account that ischaemic heart disease is the second leading cause of death in Santiago, this study quantifies the exposure-response relationship associated with the Population-Attributable Fraction that suffered ischaemic heart disease due to road traffic noise and his respective burden of disease, through the descriptor Disability-Adjusted Life Years developed by the World Health Organization. Therefore, a first introduction to this issue is addressed in this study, by comparing the data with those of studies of other cities and by providing basic background for future analysis.