Tophaceous pseudogout is a joint disease in which there is deposition of crystals of calcium pyrophosphate in articular cartilage or fibrocartilage, and usually occurs in the knees. The case is presented of a 62-year-old woman with increase in volume in the right temporomandibular joint of 2 years onset. A large mass of mixed radio-opacity surrounding the head of the condyle was observed on the computerized axial tomography. Total excision of the lesion was performed. The diagnosis of tophaceous pseudogout was obtained, by means of the histopathological examination and medical history. Two years after surgery, the patient is in good condition without signs of recurrence. The low incidence of this disease and its rare location in the temporomandibular joint can it difficult to diagnosis, thus specific studies are required to make an accurate diagnosis.