Context: Hormone replacement therapy (HRT) is the most widely used treatment for controlling the effects of menopause. This type of therapy causes some drug-related problems (DRP), which requires monitoring to control the negative effects and ensure patient adherence to therapy Aims: Perform a pharmacotherapeutic monitoring and educate to menopausal patients in HRT of a community pharmacy from the city of Antofagasta. Methods: A 98-menopausal patients underwent a pharmaceutical intervention to identify the PRM and its resolution. It was applied to them a survey before and after educational activities about this disease and HRT to determine the knowledge on the subject. Results: During the pharmacotherapeutic monitoring was determined that 55% of patients using combined HRT. 62 DRPs were detected, of which 43 were resolved (69%); the most were Patient-Pharmacist (73%). The better resolution DRP were DRP 4(b) "frequency of inadequate administration" and DRP 2(a) "no medical indication". At baseline, 90% had an inadequate level of knowledge about the disease and THR, 8% intermediate, and only 2% adequate. After the implementation of the education strategy, the level of knowledge increased, achieving at the end of the study only intermediate (10%) and adequate (90%) levels. Conclusions: The results confirm the importance of pharmaceutical intervention for the identification and resolution of DRP and the requirement to establish educational strategies to increase the knowledge about menopause and HRT in menopausal patients.