Pyoderma Gangrenosum (PG) is a rare dermatological condition characterized by rapidly progressive ulceration of the skin, with poorly defined edges and very painful. Its etiology is still unknown and far to be an infectious disease. The classic and most common form of presentation is ulcerative. There are no universal and accepted diagnostic criteria for this disease, the histologic findings and laboratory abnormalities are not specific for PG, but serve to rule out differential diagnosis. The cornerstone of treatment is the suppression of the inflammatory process and optimal wound management, to ensuring proper healing. The corticosteroids are the first line treatment. We report a case of a 23 years woman who evolves with wound dehiscence associated with tissue necrosis and purulent discharge after an emergency caesarean, not responding to broad spectrum antibiotics. The diagnosis of Pyoderma Gangrenosum was made and corticoidal treatment was started, with excellent response.