The authors aim to discuss the propensity or intention to create enterprise among university students in the region of Antofagasta, Chile, and to analyze the factors that influence the step from desire to intention. 681 students were surveyed. The data were analyzed by binary logistical regression. The results show that curriculum is among the variables that have a positive influence, while the desire for a high level of income and escaping unemployment has a negative influence on the intention. Also, being a woman has a negative influence on the intention to create enterprise. Some gender differences are discussed in this context.