The missing sepulchral monument is analysed, erected in honor of Saints Adrián and Natalia in the monastery of San Salvador and Santa María from San Adrián de las Caldas, near Boñar (León), at the end of the 13th century. Firstly, we deal with the emergence of the worship to these Saints, when their relics were moved from Byzantium to Rome and, in 9th century, its arrival to Asturias and León. In the old legionense kingdom, their remains were initially placed in an important part of the church consecrated in their honor in La Losilla, and only from 1268, they suffered another translatio to the mentioned monastery of San Salvador, place where a new arcosolium was built. The recent reappearance of their epitaphium sepulcrale, as well as other remains that formed this structure, help us to understand the increase of the saint memory in relation with the reorganization of the reliquaries that suffered the kingdom of León in that time.