This paper presents the results of research conducted in recent years on the Qhapaq Nan in the middle reaches of Quebrada de Humahuaca ravine (Jujuy, Argentina). Based on the identification of new stretches of road linked to tambos, administrative centers, strategic control points, agricultural fields and a high-altitude shrine, the authors propose that the Inca state created a new road system to connect spaces and control transit. The evidence shows that this process may have been the result of versatile policies aimed at annexing territories by incorporating local religious practices into the state religion and the resignification of local landscapes.