In the last few years, the slurry pipeline industry was faced with the challenge to consider an integral focus on the design, construction, start-up, operation and maintenance of pipeline systems in order to make them more reliable and safe. To guaranty easy and high quality of the operation, good knowledge on installed equipments and better maintenance techniques, among other aspects are required. These aspects incorporate managing a lot of activities and information regarding pipeline condition. Operation managers can easily get overwhelmed with the task of balancing the needs of maintenance with those of production and key activities required to guarantee the quality of the operation are forgotten or postponed. The work presented in this paper provides a guideline on how pipeline integrity concepts and techniques can be applied on the day-to-day operation of slurry pipelines. The guideline serves as the basis on which a more thorough studied of each operation should be made giving the operation manager a systematic application of pipeline integrity concepts well adjusted to the characteristics of the pipeline he or she is in charge of. The work methodology presented here takes into consideration aspects related to the use and maintenance of the right-of-way where the pipeline is installed and how it impacts the communities surrounding the pipeline area. The methodology focus on the preparation and training program required to deal with the daily routine operation as well as the operation and actions required in the case of an emergency or unexpected situation. In this aspect the methodology focuses on the use and need for actualization of the operating manuals and emergency response plan and manuals. The methodology also takes into consideration techniques and tools for pipeline improvement, detailing the required equipment and qualified personal for normal operation and maintenance and emergency situations.