Berberis chilensis Gillies ex Hook is an endemic Chilean plant not used in traditional medicine from which some chemical structures have been isolated. Bisenzylisoquinolinic alkaloids have been characterized as being calcium antagonists of natural origin; 7-O-Demethylisothalicberine, O-Methylisothalicberine, Berbamine, and isothalicberine have been isolated from this type of structures. Berbamina is an alkaloid that has also been isolated from a Chinese plant, which is used to prevent heart attack, along with 7-O-demethylisothalicberine are the two most important bisbenzylisoquinolinic alkaloids of this Chilean species. It shows the similarity between the chemical structures of this same family of alkaloids, where tetrandrine is perhaps the most studied structure and has been characterized as one of the most important calcium antagonists, isolated from the Chinese plant Stephania tetrandra which is used from about 500 years before Christ as a medicinal plant by the Chinese people.