Autoimmune retinitis comprises a spectrum of diseases that share clinical features and pathophysiology, which refers to the presence of retinal antibodies that produce panretinal degeneration. The clinical features are progressive and painless visual acuity loss associated with photopsia, entopsia and nyctalopia, with a normal fundus in many cases. The history of neoplastic disease is important regarding diagnosis, treatment and prognosis when suspecting this entity. It is necessary to rely on the Goldmann visual field, macular OCT, electroretinography and retinal antibodies to confirm the diagnosis. This disease represents a challenge for the ophthalmologist given the absence of standardized diagnostic criteria. The purpose of this paper is a brief review of the disease and describing three cases of autoimmune retinitis who attended the Andes Ophthalmological Foundation.