Statement of Purpose: Gelatin (G) is a high biodegradable and biocompatible natural biopolymer. G can interact with graphene oxide (GO) to produce aerogels by means covalent and noncovalent interactions and so, to avoid GO cytotoxicities issues. These aerogels have a high absorption capacity and favorable surface properties, which allows them to interact with blood, acting as a hemostatic device. In addition, these aerogels can be loaded with polyphenols, which could modify their surface and properties changing their clotting behavior. The objective of this study was to develop an aerogel GO-G by means covalent and noncovalent interactions, with and without proanthocyanidins (tannins) extracted from Pais grapes, to evaluate it as a hemostatic device. Therefore, their surface properties, blood coagulation behavior, and cytotoxicity were determinated and compared.