A study of spatial variability in some physical and chemical properties of a soil of the Quipato Series (Ultic Palexeralfs) of Cauquenes Province (coordinates 753.677 E; 6.014.001 N, UTM Datum WGS84 Zona 18), 7th Region, Chile, was conducted to determine the d6egree of spatial correlation with grape (Vitis vinifera L.) yield and must quality variables measured in two blocks of cv. Cabernet Sauvignon and one block of cv. Chardonnay. The sampling method used was a systematic grid with a density of 10 sampling points per hectare. The data were analyzed using geostatistical techniques. A spatial dependency analysis was performed. The spatially correlated variables were grouped via an analysis of factors to later define homogeneous treatment zones through cluster analysis. The results indicated that the sampling intensity used was not sufficient to characterize the spatial variability of grape yield and must quality in the block corresponding to the cv. Chardonnay and there was no spatial correlation with the soil properties evaluated. In the two blocks of the cv. Cabernet Sauvignon, the spatial variability of number of clusters, pruning weight and must pH were characterized, nevertheless, only the number of clusters had a spatial correlation with the evaluated soil properties. The number of samples per hectare necessary to characterize the spatial variability of the soil properties and the grape yield and must quality is site-specific and different for each variable to be evaluated.