The variability of the diet was considered according to seasonality and day of the week in women aged 47 to 61 years. The research design was based in a prospective and factorial case study. From a universe of 268 women, a sample of 23 volunteers was obtained. The instrument was a food survey with information recorded from Monday to Friday (MF) and Saturday and Sunday (WE) for two seasonal periods: Spring-Summer (SS) and Autumn-Winter (AW). Data on the intake of macronutrients, alcohol, calcium, iron, vitamin C and fiber was statistically analyzed (ANOVA). The results indicate that the caloric intake was greater on WE and in AW (p<0.05). Protein and lipid intake is greater on WE, cholesterol was of greater relative consumption in AW of MF and WE with 98.7% and 121% respectively. Carbohydrates iron, vitamin C and dietary fiber were slightly greater, and calcium was significantly greater in AW. The intra-individual variability was minor than the inter-individual variation. We conclude that seasonality and the particular day of the week influence the consumption of energy, proteins, cholesterol and calcium in this group of women, and could constitute a nutritional risk factor