Coffee is one of the most widely consumed beverages in the world due to its organoleptic properties and its ability to keep individuals alert. However, its consumption is frequently associated with negative health effects. This paper reviews the most recent information about the relation between coffee and health. A number of epidemiological studies carried out in the last decade consistently show that coffee intake is related to a lower risk of type-2 diabetes, liver damage, and neurodegenerative diseases such as Parkinson. The mechanisms which could explain these observations are not clearly understood yet, but they could be related to the unique profile and high concentrations of antioxidants in coffee, particularly chlorogenic acid