The influence by the addition of whey proteins on the biochemical changes in Chanco cheese ripening was evaluated. 4 treatments were set up: TC (control), and TI, T2 and T3 adding milk whey powder at 2, 4, 6% (m/m) respectively using a factorial design 3 x4 (4 treatments by 3 repetitions). In pH control, humidity, fat, total solids, proteins, ashes and salt at 0, 14, 28 and 42 days, standardized methods were used: IDF-FIL, AOAC and Chilean guidelines. Color by colorimeter Color test LFM1, water activity by the LUF analyzer and by the formula. In the sensorial evaluation the test of Multiple Comparison (4 attributes) was used. The results showed that glycolysis increased during ripening in treatments with whey. Moisture, fat and ashes increased at T2 & T3, and water activity decreased slowly in cheeses. Control and TI in texture profile were statistically equal. It is concluded that whey addition to Chanco cheese it is feasible but limited.