The cutting fluids contributed for removing chips, cooling, and lubricating, on the other hand, are harmful to the environment. The minimum quantity lubrication technique (MQL) in machining operations proved to be suitable in addition to minimizing the environmental impact. The present work is focused on the drilling of electrolytic copper using biodegradable oil as cutting fluids applied by the MQL technique. The specific cutting pressure, burr height, and maximum diameter were measured varying the cutting parameters, cutting speed, feed, and lubrication condition (dry, flooded, and MQL). A statistical analysis was utilized to determine the influence of cutting parameters in the variables measured. The results indicated that the second-order interactions have a significant influence on the specific cutting pressure and in burr height. The lowest burr height was obtained using flood and MQL. The MQL system demonstrated the lowest specific cutting pressure, while the flood exhibited the best performance for diameter analysis. In addition to this, it can be confirmed that the MQL technique may replace the flooding drilling (abundant flow), minimizing the environmental impact.