Introduction. Antidepressants have been associated with the induction of hipomania and mania. Methods. We reviewed several reports and review papers in publications on this field. Results. The antidepressant-associated mania occurs more frequently in bipolar depression, the use of tricyclic antidepressants and it is directly associated with the duration of treatment. No qualitative clinical differences have been found between the induced manic or hipomanic episodes and the spontaneous ones. Conclusions. Unipolar patients who switch with the use of antidepressants happened to be bipolar who have not develop the other phase on a spontaneous manner. Clinical switch is the best predictor for the development of a bipolar disease with a 100% specificity. This is why these patients are called"pseudo-unipolar", and are classified within the bipolar spectrum as "type III bipolar disorder