To introduce innovation in clinical practice is a difficult task. Although there is no universal recipe, education of involved actors has been identified as a key factor, including managers, health care workers, patients, and community. Managers in charge of developing and implementing new clinical guidelines bear great responsibility, and need formal education on the appraisal of evidence and the analysis of available resources, to ensure the quality of the product that will be delivered. Although continuous education and training is widely perceived as valuable activities, people need to be encouraged to participate in them. Incentives for fostering participation are needed, and they should be carefully planned. The contents of the training programs should be tailored to the different audiences and they should be delivered in attractive manner, in small groups, using modern interactive educational technology