The objective of our study was to describe the experience in US-guided core biopsy of the Radiology Department of Hospital Padre Hurtado. Case files of women that had undergone core biopsy during 2005 and the first semester of 2006 were retrospectively reviewed, obtaining basic demographic data, mammography and ultrasound reports, and results of core biopsy and surgical biopsy, when these were available. Our study population consisted of 37 women with a mean age of 49.8 ± 11.0 years. The main indication for core biopsy was breast nodule (91.7%). A 67.6% of core biopsies were benign and the remaining 32.4% were indicative of malignancy. 15 women had surgical excisions, all of those with indicative malignant core biopsies (12), and 3 with benign ones. Only two surgical biopsies were not consistent with their previous core, with a Spearman correlation coefficient of 0.72 (high), p = 0.0001. Core biopsy at Hospital Padre Hurtado showed high correlation with surgical biopsy, and, was useful avoiding unnecessary surgeries of benign lesions