Ultrasound is a useful diagnostic modality to study many structures such as subcutaneous tissue, tendons, muscles, joints, and nerves. It has low cost, wide availability and high resolution. These advantages make ultrasound a good modality in interventional procedures like soft tissue tumors biopsy, aspiration of cysts and other collections, and also in treating symptomatic calcifications like deposition of hidroxiapatite crystals in the rotator cuff, among other indications. Our objetive is to present the experience of the authors in performing musculoskeletal interventional procedures by ultrasound.