In this work, we studied how the incorporation of three different monoalkyl mannoside derivatives in synthetic bilayers modify their physical-chemical properties (transition temperature, fluidity) or promotes their solubilization. Determinations were made by using fluorescence spectroscopy, colorimetry and optical density measurements. Our results showed first that the mannoside derivatives behave different from other alkyl monosaccharides previously reported, such as glucosides and galactoside. Second, the ability of mannose derivatives to solubilize membranes dependents on its structure (length of alkyl chain) and the affinity between man nose derivatives and the lipid bilayer does not only depend on their Hydrophilic Lipophilic Balance, but also on the effect of the packing capabilities of the hydrophilic sugar head. (C) 2019 Elsevier B.V. All rights reserved.