Background: Differentiated thyroid cancer has a good prognosis. If there is local tumor infiltration, the prognosis depends on its complete excision. Case report: We report a 67 years old woman with a papillary thyroid cancer and a bleeding skin ulcer. The initial assessment disclosed local tumor infiltration of neck structures and cervical lymph nodes. She was subjected to a radical thyroidectomy, radical neck dissection and dissection of involved structures. She was also treated with radioiodine and levothyroxine and remains asymptomatic after two years of follow up