Throughout Earth's most extreme environments, such as the Kalahari Desert or the Arctic, hunter-gatherers found ingenious ways to obtain proteins and sugars provided by plants for dietary requirements. In the hyperarid Atacama Desert, wild plant resources are scarce and unevenly distributed due to limited water availability. This study brings together all available archaeobotanical evidence gathered in the Atacama Desert from the Late Pleistocene (ca. 13,000 cal bp) until the Inka epoch (ca. 450 cal bp) to help us comprehend when these populations acquired and managed useful plants from the coastal zone, Intermediate Depression, High Andes, as well as tropical and subtropical ecosystems. Widespread introduction of farming crops, water control techniques and cultivation of diverse plants by 3,000 cal bp ended not only a chronic food shortage, but also led to the establishment of a set of staple foods for the Atacama Desert dwellers, a legacy that remains visible today. By contrasting these trends with major sociocultural changes, together with palaeodemographic and climatic fluctuations, we note that humans adapted to, and transformed this hyperarid landscape and oscillating climate, with plants being a key factor in their success. This long-term process, which we term the "Green Revolution", coincided with an exponential increase in the number of social groups inhabiting the Atacama Desert during the Late Holocene.