We present geomorphic, stratigraphic, and chronological data acquired along theGeneral Carrera-Buenos Aires (GCBA) glacial lake located along a major morphological incision across the Andes. Complementing relevant available data, relative chronology of morphoclimatic records together with 18 Be-10 cosmic ray exposure ages allow constraining the timing of the Patagonian ice sheet fluctuations since the last glacialmaximum. It improves the knowledge of Patagonia climate evolution in the 46 degrees-48 degrees S area and allows documenting the uplift rates (glacial rebound) for the past similar to 7-9 ka. The first major ice lobe retreat occurred after 17.3 +/- 0.6 ka and has likely continued during the Antarctic cold reversal from similar to 12.9 to 14.5 ka. Between similar to 12.9 and similar to 10.9 +/- 1.3 ka, the General Carrera Lake evolved as an endorheic basin. Terraces T4-T1 (top to bottom) have recorded abrupt lake regressions likely controlled by rainfall deficit. They have accumulated in the time interval similar to 17.3-12.3 ka (maximum limits). Two glacial re-advances at similar to 10.9 +/- 1.3 and similar to 7.9 +/- 1.1 ka marked a major climate change that led the lake to be ice dammed again. A major transgression occurred that subsequently flooded the previously accumulated terraces. Since then, a pervasive regression has steered the GCBA Lake to the situation at present. The highest shoreline of the transgression is used as a passive marker in order to quantify the magnitude and character of the regional deformation. At long 72 degrees 30'W, the GCBA Lake area uplifted (glacial rebound) at a rate between 15 and 33.5mm yr(-1) during the past similar to 7.9 +/- 1.1 ka. We infer that the high uplift rate mainly originates from the North Patagonian icefield ice loss.