Dataciencia

Colección SciELO Chile

Glucocorticoid Receptor-α and MKP-1 as Candidate Biomarkers for Treatment Response and Disease Activity in Vogt-Koyanagi-Harada Disease

Indexado

WoS	WOS:000504341100033
Scopus	SCOPUS_ID:85071312277

DOI

10.1016/J.AJO.2019.06.032

Año

2019

Tipo

artículo de investigación

Citas Totales

Autores Afiliación Chile

Instituciones Chile

% Participación
Internacional

Autores
Afiliación Extranjera

Instituciones
Extranjeras

Abstract

CONCLUSIONS: In this pilot study, the expression of GR isoforms and MKP-1 corresponded with patients' clinical response to systemic CS treatment and disease activity, respectively. Hence, these candidate biomarkers have potential clinical utility in the early identification of CS refractoriness and subclinical inflammation in patients with VKH disease. (C) 2019 Elsevier Inc. All rights reserved.

Revista

Revista	ISSN
American Journal Of Ophthalmology	0002-9394

Métricas Externas

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Disciplinas de Investigación

WOS
Ophthalmology

Scopus
Ophthalmology

SciELO
Sin Disciplinas

Muestra la distribución de disciplinas para esta publicación.

Publicaciones WoS (Ediciones: ISSHP, ISTP, AHCI, SSCI, SCI), Scopus, SciELO Chile.

Colaboración Institucional

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Autores - Afiliación

Ord.	Autor	Género	Institución - País
1	URZUA-SALINAS, CRISTHIAN ALEJANDRO	-	Universidad de Chile - Chile Universidad del Desarrollo - Chile NEI - Estados Unidos National Eye Institute - Estados Unidos National Eye Institute (NEI) - Estados Unidos
2	Chen, P.	-	NEI - Estados Unidos National Eye Institute - Estados Unidos National Eye Institute (NEI) - Estados Unidos
3	Chaigne-Delalande, Benjamin	Hombre	NEI - Estados Unidos National Eye Institute - Estados Unidos National Eye Institute (NEI) - Estados Unidos
4	Liu, Baoying	-	NEI - Estados Unidos National Eye Institute - Estados Unidos National Eye Institute (NEI) - Estados Unidos
5	Anguita, Rodrigo Montes	Hombre	Universidad de Chile - Chile
6	GUERRERO-PERALTA, JULIA ADRIANA	Mujer	Universidad de Chile - Chile
7	SABAT-KIRKWOOD, PABLO	Hombre	Universidad de Chile - Chile
8	Velásquez, Víctor	Hombre	Universidad de Chile - Chile
9	Sen, H. Nida	-	NEI - Estados Unidos National Eye Institute - Estados Unidos National Eye Institute (NEI) - Estados Unidos
10	Lee, Richard W. J.	Hombre	Univ Bristol - Reino Unido Natl Hlth Serv Fdn Trust - Reino Unido University of Bristol - Reino Unido Moorfields Eye Hospital NHS Foundation Trust - Reino Unido
11	GOECKE-SARIEGO, IRMGADT ANNELISE	Mujer	Universidad de Chile - Chile

Muestra la afiliación y género (detectado) para los co-autores de la publicación.

Financiamiento

Fuente
Universidad de Chile
Intramural Research Program of the US National Institutes of Health/National Eye Institute
Vicerrectoria de Investigacion y Desarrollo (University of Chile)
National Institute for Health Research (NIHR) Biomedical Research Centre
Moos-fields Eye Hospital National Health Service Foundation Trust
University College London Institute of Ophthalmology
National Institute for Health Research
NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
Department of Health, Australian Government
Vicerrectoria de Investigacion y Desarrollo
UCL Institute of Ophthalmology, University College London
National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology
US National Institutes of Health/National Eye Institute

Muestra la fuente de financiamiento declarada en la publicación.

Agradecimientos

Agradecimiento
This study was supported by the Intramural Research Program of the US National Institutes of Health/National Eye Institute and by Vicerrectoria de Investigacion y Desarrollo (University of Chile) grant 560872-PR. The funding organizations had no role in the design or conduct of this research. Dr. Lee has received support from National Institute for Health Research (NIHR) Biomedical Research Centre, Moos-fields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology. The views expressed are those of the authors and not necessarily those of the National Health Service, the NIHR or the Department of Health.
All authors have completed and submitted the ICMJE form for Disclosure of Potential Conflicts of Interest and none were reported. Financial Disclosures: Drs. Urzua and Goecke hold patent rights (University of Chile). Funding/Support: This study was supported by the Intramural Research Program of the US National Institutes of Health/National Eye Institute and by Vicerrectoria de Investigacion y Desarrollo ( University of Chile ) grant 560872-PR . The funding organizations had no role in the design or conduct of this research. Dr. Lee has received support from National Institute for Health Research (NIHR) Biomedical Research Centre , Moorfields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology . The views expressed are those of the authors and not necessarily those of the National Health Service, the NIHR or the Department of Health.

Agradecimiento

This study was supported by the Intramural Research Program of the US National Institutes of Health/National Eye Institute and by Vicerrectoria de Investigacion y Desarrollo (University of Chile) grant 560872-PR. The funding organizations had no role in the design or conduct of this research. Dr. Lee has received support from National Institute for Health Research (NIHR) Biomedical Research Centre, Moos-fields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology. The views expressed are those of the authors and not necessarily those of the National Health Service, the NIHR or the Department of Health.

All authors have completed and submitted the ICMJE form for Disclosure of Potential Conflicts of Interest and none were reported. Financial Disclosures: Drs. Urzua and Goecke hold patent rights (University of Chile). Funding/Support: This study was supported by the Intramural Research Program of the US National Institutes of Health/National Eye Institute and by Vicerrectoria de Investigacion y Desarrollo ( University of Chile ) grant 560872-PR . The funding organizations had no role in the design or conduct of this research. Dr. Lee has received support from National Institute for Health Research (NIHR) Biomedical Research Centre , Moorfields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology . The views expressed are those of the authors and not necessarily those of the National Health Service, the NIHR or the Department of Health.