A 45 years old male in whom a Hodgkin disease, nodular sclerosis variety, IIIBS, with splenectomy was diagnosed at the age of 2 7 years of age, is reported. He was treated initially with chemotherapy C-MOPP and radiotherapy obtaining a complete remission of the disease two years later. In December 2000, after 17 years of remission, the disease relapsed with generalized lymph node enlargement and lung involvement. He was treated with ABVD chemotherapy but died after 5 cycles due to a febrile neutropenia, bronchopneumonia and respiratory distress (Rev Med Cbile 2003; 131: 197-9).